CAS No.: 57-83-0
Molecular formula: C21H30O2
Molecular weight: 314.46
Introduction: Progesterone (English: progesterone, also known as progesterone, progesterone, progesterone, progesterone, progesterone, progesterone or progesterone, abbreviated as P4, also known as (progesterone-4-en-3,20-dione), is an endogenous steroid and progesterone sex hormone, and also the main progesterone in the body, secreted by the female ovary. Progesterone is a steroid hormone containing 21 carbon atoms secreted by the luteal cells of the ovary. It is also an intermediate product of the synthesis of all steroid hormones, belonging to one of the progesterones. There are two crystal forms, namely α- Type and β- The two crystal forms have the same physiological activity, α- Type B is precipitated from dilute ethanol, which is orthorhombic white prismatic crystal, β- Type A is a white needle crystal of orthorhombic crystal system, both of which are insoluble in water, but soluble in ethanol, ether, chloroform, acetone, dioxane and concentrated sulfuric acid.
Purpose: progesterone has significant morphological effect on the endometrium stimulated by estrogen in vivo, which is necessary for maintaining pregnancy. In the late menstrual period, estrogen and estrogen promote the development and proliferation of endometrium, making it change from proliferative phase to secretory phase, creating conditions for the implantation of fertilized eggs and the development of embryos; During menstruation, the endometrium falls off completely; Inhibit the movement of the uterus and the sensitivity to oxytocin during pregnancy, have the effect of calming the fetus, and promote the further development of the mammary gland together with estrogen to prepare for milk production; Large doses can inhibit the secretion of luteinizing hormone by the anterior pituitary through the feedback regulation of the hypothalamus-pituitary-ovarian axis, thus inhibiting ovulation and playing a contraceptive role. Progesterone can be used for habitual abortion, threatened abortion, uterine functional bleeding, blood avalanche, dysmenorrhea, endometriosis, amenorrhea, ureteral calculus. Prostatic hyperplasia, sleep apnea syndrome and refractory cirrhosis ascites.
