Dehydroepiandrosterone

CAS No.: 53-43-0




Molecular formula: C19H28O2




Molecular weight: 288.43




Overview: Dehydroepiandrosterone (DHEA), chemical name 3 – β– Hydroxyandrosterone – 5 – ene – 17 – one, also known as dehydroepiandrosterone, is a kind of cholesterol △ 5, 6 double bond and esterified 3 – β– Hydroxysteroids, with the molecular formula of C19H28O2, molecular weight of 288.41, melting point of 151 ℃~153 ℃, and optical rotation of+5.5 °, are precursors of adrenal hormones secreted by the reticular layer of the human adrenal cortex. They have physiological activities such as regulating obesity, preventing diabetes, anti-cancer and virus infection, improving memory, immune response and stress response, and reducing tension. They are intermediates for manufacturing steroid hormones and participate in the synthesis of multiple hormones secreted by the adrenal glands. Physical and chemical properties: two crystal forms. Acicular crystal, melting point 140~141 ℃; Lobular lamellar crystal, melting point 152~153 ℃. It has right optical rotation. Soluble in ethanol, ether and benzene, slightly soluble in chloroform and petroleum ether. Precipitation occurs when meeting with digitalis saponin.




Physiological activity: 1. Prevention and treatment of obesity DHEA has thyroid-like effect, can inhibit food and fat intake, reduce fat accumulation, etc. Oral low-dose DHEA sulfate has certain effect on improving the quantity and distribution of body fat and lowering blood fat. In addition, DS can act on mitochondrial respirator, inhibit food and fat intake, and is related to DHEA's resistance to glucocorticoids, which can prevent obesity. 2. Anti diabetes DHEA can improve glucose tolerance, insulin level and anti diabetes. 3. Anti-cortical disease DHEA can enhance the activity of endocrine system, reduce the level of cortisol, and resist various pathological processes. After taking DHEA, the symptoms of patients with systemic lupus erythematosus (SLE) have been greatly improved, indicating that DHEA has a certain effect on SLE. DHEA can help the human body obtain cortical antibodies. The concentration of DHEA in plasma is closely related to various cortical diseases. The lower the concentration, the greater the risk of disease. 4. Anticancer DHEA has a certain role in preventing and inhibiting tumor growth. First, it is clinically found that the anticancer effect of DHEA is related to reversing breast cancer. Low level DHEA is associated with bladder cancer and gastric cancer, but not with age. It has been confirmed that DHEA has protective and synergistic effects when used in chemotherapy of tumors. Because DHEA has the effect of inhibiting ribose 5 phosphate, DHEA has the effect of inhibiting cancer by inhibiting excessive mitochondria (NADPH) and ribose 5 phosphate. DHEA can inhibit the growth of pancreatic cancer cells. It is speculated that the mechanism is that DHEA inhibits the growth of pancreatic cancer cells by regulating the alternate changes of estrogen concentration in plasma. 5. The content of DHEA in the body of people with anti-aging effect is the highest at the age of 25-30 years old, and will gradually decline after 30 years old, with an annual decline rate of about 2%. By the age of 70 years old, the content of DHEA in the body has decreased to less than 25% when they are young; At the same time, the incidence rate of geriatric diseases related to the decline of DHEA also increased. The decline of GnRH gene expression function leads to aging. It is believed that DHEA can restore the activity of GnRH neurons and prevent or improve some diseases related to the decline of DHEA by stimulating GnRH biosynthesis. 6. Immune response DHEA can recover the damaged immune response and improve the immune function of T cells and B cells. DHEA plays an important role in improving the physiological activity of insulin-like growth factor (IGF-1) and is a potential beneficial drug for the treatment of immune deficiency. 7. Effect on bone DHEA itself cannot directly and independently affect the growth and differentiation of human osteoblasts, but it can achieve the growth and differentiation of osteoblasts by affecting the changes of 1,25-dihydroxyvitamin D3. The effect of DHEA on bone depends on the form of sex hormone in bone cells and its endocrine effect on osteoblasts. 8. Protein metabolism DHEA is a protein assimilation hormone, which can promote protein synthesis. According to Marrero et al., feeding mice with DHEA (0.45%) can increase liver weight, increase liver mitochondria and restore RNA and protein synthesis through liver protein induction. 9. In other aspects, DHEA has conducted extensive clinical research on the treatment of menopausal syndrome, scleroderma, coronary heart disease, gout, psoriasis, AIDS, etc. The study also found that the pathogenesis of tuberculosis cytoplasmic deformation was related to the concentration of adrenocortical hormone and anti adrenocortical hormone; The concentration of cortisol/DHEA-S in fetal plasma is closely related to the delivery period.


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